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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:ibandronate pharmacodynamics pathway
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Accession:PW:0002002 term browser browse the term
Definition:The pathway of ibandronate-target interaction and of the biochemical or physiological responses to drug. Ibandronate is a nitrogenous bisphosphonate drug used to treat bone diseases. Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00079

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ibandronate pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAT2 acetyl-CoA acetyltransferase 2 ISO SMPDB SMP:00079 NCBI chr13:87,363,527...87,378,002 JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 ISO SMPDB SMP:00079 NCBI chr21:56,865,498...56,888,196
Ensembl chr21:56,865,312...56,886,698 		JBrowse link
G DHCR24 24-dehydrocholesterol reductase ISO SMPDB SMP:00079 NCBI chr20:78,052,565...78,088,918
Ensembl chr20:78,052,607...78,086,303 		JBrowse link
G EBP EBP cholestenol delta-isomerase ISO SMPDB SMP:00079 NCBI chr  X:45,652,398...45,660,551
Ensembl chr  X:45,653,356...45,660,291 		JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 ISO SMPDB SMP:00079 NCBI chr 8:7,272,580...7,306,859
Ensembl chr 8:7,271,509...7,306,760 		JBrowse link
G FDPS farnesyl diphosphate synthase ISO SMPDB SMP:00079 NCBI chr20:8,514,311...8,526,363 JBrowse link
G GGPS1 geranylgeranyl diphosphate synthase 1 ISO SMPDB SMP:00079 NCBI chr25:72,502,333...72,517,349 JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase ISO SMPDB SMP:00079 NCBI chr 4:69,664,784...69,690,343
Ensembl chr 4:69,665,417...69,688,686 		JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 ISO SMPDB SMP:00079 NCBI chr 4:42,083,523...42,107,410
Ensembl chr 4:42,080,949...42,107,409 		JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 ISO SMPDB SMP:00079 NCBI chr20:1,271,259...1,289,232
Ensembl chr20:1,273,052...1,288,930 		JBrowse link
G IDI1 isopentenyl-diphosphate delta isomerase 1 ISO SMPDB SMP:00079 NCBI chr 9:995,608...1,011,226
Ensembl chr 9:996,909...1,003,963 		JBrowse link
G LIPA lipase A, lysosomal acid type ISO SMPDB SMP:00079 NCBI chr 9:82,639,220...82,677,479
Ensembl chr 9:82,638,621...82,677,488 		JBrowse link
G LSS lanosterol synthase ISO SMPDB SMP:00079 NCBI chr 2:89,809,065...89,846,295
Ensembl chr 2:89,811,698...89,846,242 		JBrowse link
G MSMO1 methylsterol monooxygenase 1 ISO SMPDB SMP:00079 NCBI chr 7:111,688,591...111,704,765
Ensembl chr 7:111,688,604...111,704,849 		JBrowse link
G MVD mevalonate diphosphate decarboxylase ISO SMPDB SMP:00079 NCBI chr 5:74,031,470...74,049,066
Ensembl chr 5:74,031,316...74,049,011 		JBrowse link
G MVK mevalonate kinase ISO SMPDB SMP:00079 NCBI chr11:104,812,882...104,837,089
Ensembl chr11:104,813,846...104,835,517 		JBrowse link
G NSDHL NAD(P) dependent steroid dehydrogenase-like ISO SMPDB SMP:00079 NCBI chr  X:127,342,788...127,389,117
Ensembl chr  X:127,342,850...127,390,536 		JBrowse link
G PMVK phosphomevalonate kinase ISO SMPDB SMP:00079 NCBI chr20:8,893,297...8,906,882
Ensembl chr20:8,894,786...8,906,873 		JBrowse link
G SC5D sterol-C5-desaturase ISO SMPDB SMP:00079 NCBI chr 1:112,706,511...112,720,860
Ensembl chr 1:112,706,545...112,719,722 		JBrowse link
G SOAT1 sterol O-acyltransferase 1 ISO SMPDB SMP:00079 NCBI chr25:49,998,197...50,061,433
Ensembl chr25:50,001,910...50,061,173 		JBrowse link
G SQLE squalene epoxidase ISO SMPDB SMP:00079 NCBI chr 8:119,586,639...119,610,980
Ensembl chr 8:119,586,659...119,611,142 		JBrowse link
G TM7SF2 transmembrane 7 superfamily member 2 ISO SMPDB SMP:00079 NCBI chr 1:9,112,528...9,117,201
Ensembl chr 1:9,112,710...9,116,898 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4034
    drug pathway 383
      musculo-skeletal system drug pathway 65
        bisphosphonate drug pathway 22
          nitrogenous bisphosphonate drug pathway 22
            ibandronate drug pathway 22
              ibandronate pharmacodynamics pathway 22
paths to the root